Cloned (Comment) | Organism |
---|---|
ectopic expression of either wild-type Jhdm1a or H212A point mutant in the liver of diabetic ob/ob mice | Mus musculus |
ectopic expression of Jhdm1a in HeLa and wild-type and enzyme-deficient Hep-G2 cells via lentivirus transfection | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H212A | inactive mutant | Mus musculus |
additional information | Jhdm1a knockdown or scramble adenoviruses are transduced into the liver of wild-type male C57BL/6J mice | Mus musculus |
additional information | shRNA knockdown of Jhdm1a in Hep-G2 cells elevating gluconeogenic gene expression | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | Mus musculus | Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | Homo sapiens | Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | Mus musculus C57/BL6J | Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 | Mus musculus | - |
protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? | |
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 | Homo sapiens | Jhdm1a actively demethylates dimethylated H3K36 on the C/EBPalpha locus | protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? | |
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 | Mus musculus C57/BL6J | - |
protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Mus musculus C57/BL6J | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
hepatocyte | primary | Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | - |
Mus musculus | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | - |
Homo sapiens | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 | Mus musculus | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 | Homo sapiens | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | - |
Mus musculus C57/BL6J | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 | Mus musculus C57/BL6J | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 | - |
Mus musculus | protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? | |
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 | - |
Homo sapiens | protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? | |
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 | Jhdm1a actively demethylates dimethylated H3K36 on the C/EBPalpha locus | Homo sapiens | protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? | |
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 | - |
Mus musculus C57/BL6J | protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H3K36 demethylase | - |
Mus musculus |
H3K36 demethylase | - |
Homo sapiens |
histone H3 lysine 36 demethylase | - |
Mus musculus |
histone H3 lysine 36 demethylase | - |
Homo sapiens |
JHDM1A | - |
Mus musculus |
JHDM1A | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | Jhdm1a knockdown mice are still able to maintain normal glycemia, but display higher glucose production upon injection of the gluconeogenic substrate pyruvate | Mus musculus |
malfunction | silencing of Jhdm1a promotes liver glucose synthesis, while its exogenous expression reduces blood glucose level in vivo | Homo sapiens |
additional information | expression of the wild-type Jhdm1a, but not the H212A point mutant, decreased the expression of PEPCK and G6Pase in diabetic ob/ob mice | Mus musculus |
physiological function | histone demethylase Jhdm1a regulates hepatic gluconeogenesis, regulation of gluconeogenesis by Jhdm1a requires its demethylation activity. Jhdm1a is a key negative regulator of gluconeogenic gene expression. Jhdm1a regulates the expression of a major gluconeogenic regulator, C/EBPalpha, by its USF1-dependent association with the C/EBPa promoter and its subsequent demethylation of dimethylated H3K36 on the C/EBPa lpha locus | Homo sapiens |
physiological function | Jhdm1a has a physiological role in hepatic gluconeogenesis in vivo, and this role is mediated by its histone demethylation activity | Mus musculus |